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You are here:Home » Antibodies » Abs to Enzymes, Acetyltransferase » Anti -Choline Acetyltransferase (CHAT, CMS1A, CMS1A2, Acetyl CoA:choline O-acetyltransferase)

Anti -Choline Acetyltransferase (CHAT, CMS1A, CMS1A2, Acetyl CoA:choline
O-acetyltransferase)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Applications:
Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Catalog #C5057-01
Recommended DilutionImmunohistochemistry 1:100
Western Blot 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid.
PuritySerum
ImmunogenSynthetic peptide corresponding to native choline acetyltransferase purified from human placenta.
SpecificityRecognizes human 68/70 k choline acetyltransferase protein. Species Crossreactivity: Chicken, guinea pig, mouse, non-human primate and rat tissues.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesChat, CHAT, CMS1A, CMS1A2, Acetyl CoA:choline O-acetyltransferase


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