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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Chondroitin Sulfate (Chondroitin Sulfate Proteoglycan, CSPG)

Anti -Chondroitin Sulfate (Chondroitin Sulfate Proteoglycan, CSPG)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IH IF
The NG2 chondroitin sulfate proteoglycan is a valuable marker for many types of immature progenitor cells including pericytes/smooth muscle cells, chondroblasts and oligodendrocyte progenitors. NG2 is often expressed in melanomas, chondrosarcomas, glioblastomas and myeloid leukemias. Studies indicate that NG2 is involved in modulating cellular response to growth factors and cell motility; these are critical functions in proliferation and migration of immature progenitor cells and tumor cells. Oligodendrocyte precursor cells (OPCs) are a population of NG2 expressing cells in the brain that accumulate in response to CNS injuries. OPCs, together with microglia and astrocytes, form the glial scar, which is believed to inhibit or prevent axonal regeneration partly by producing growth inhibiting NG2 at the injury site8. It has been suggested that inhibiting NG2 at sites of spinal cord injury may increase beneficial axonal regeneration. Studies suggest that NG2 stimulates tumor growth and neovascularization in glioblastoma multiforme by inhibiting angiostatin and thus promoting angiogenesis. As NG2 is associated with increased tunmor cell proliferation, it may be a potential therapeutic marker in brain tumors.
Catalog #C5067-70M
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Frozen): 1:100-1:400
Immunofluorescence: 1:100-1:400
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No10B2233
HostMouse
SourceChicken
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide.
PurityAscites
ImmunogenVentral membranes of chicken gizzard fibroblasts.
SpecificityRecognizes chondroitin sulfate-containing proteoglycans. Reacts specifically with chondroitin sulfate of both types A and C but not with type B (dermatan sulfate). Gives positive staining in bovine mammary gland epithelial cells and human, chicken and mouse fibroblast or tissues. Species Crossreactivity: bovine, human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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