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You are here:Home » Molecular Biology » MB-Hormones, Steroids » Chorionic Gonadotropin, Human (hCG)

Chorionic Gonadotropin, Human (hCG)

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Specifications

Human Chorionic Gonadotropin (HCG) is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the a-and b-subunits. The a-subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP), and HCG but negative for EMA and AFP is probably a choriocarcinoma.
Human Chorionic Gonadotropin (hCG) is produced from a sterile preparation of placental glucoprotein urine of post-menopausal women having a total molecular mass of 36,700 Dalton. hCG consists of 237 amino acids, chain-92 amino acids and chain-145 amino acids. The hCG is purified by proprietary chromatographic techniques.
Catalog #C5069-21A
Biological ActivityUnited States Biologicalís hCG is biologically active compared to standard. The biological activity of hCG is determined by using the seminal vesicle weight gain test in male rats described in the "Chorionic Gonadotrophins" monograph of the European Pharmacopoeia. The in vivo biological activity of hCG has been calibrated against the third international reference preparation IS75/587 for chorionic gonadotropin. The Specific Activity was found to be 5000 IU/mg.
CONTAMINANTSThe product is free of HbsAg, Hepatitis B surface antigen, and antibodies to HIV, Hepatitis C and HCV.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Stable for at least 6 months at -20°C. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Further dilutions can be made in assay buffer.
SourceUrine of post-menopausal women
Purity98% (SDS-PAGE and HPLC)
FormSupplied as a sterile-filtered, white lyophilized powder. Reconstitute with sterile dH2O, 0.1% HSA or BSA to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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