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You are here:Home » Antibodies » Abs to Chromogranin » Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1,
Pituitary secretory protein I, Vasostatin, SPI)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified IH
The chromogranins (A, B, and C) are major components of dense core granules of neuroendocrine cells and sympathetic nerves. They constitute a widely distributed family of acidic soluble proteins which range in molecular weight from 76-120kD. Each polypeptide subunit shares the some sequence homology. Polyclonal chromogranin A antibody is useful in the identification of neuroepthelial and neuroendocrine differentiation in neoplastic cells. It may be used with other neuroendocrine markers such as NSE, MOC-32, CD56, and synaptophysin to improve the tumor diagnosis.
Catalog #C5069-96E
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Frozen and formalin-fixed, paraffin-embedded tissue sections using light microscopy
Optimal dilutions to be determined by the researcher.
Positive ControlHuman pancreas or neuroendocrine tumor that has been previously shown to express Chromogranin A
Epitope Retrieval Not Required
Enzyme Digestion Not Required
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.05mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenPurified Chromogranin A from human tissue with carcinoid syndrome. Expected Staining Pattern: Cytoplasmic.
SpecificityRecognizes human Chromogranin A fragments located at the C-terminal half, but not with fragments located at the N terminal half of the polypeptide. Recacts with Chromogranin A, which is present in the secretory vesicles of neuroendocrine cells such as in pancreas, adrenal medulla, pituitary, and thyroid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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