Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Chromogranin » Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1,
Pituitary secretory protein I, Vasostatin, SPI)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Rabbit Affinity Purified E B IH
Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Chromogranin A (CGA) is the major member of the granin family of acidic secretory glycoproteins that are expressed in all endocrine and neuroendocrine cells. Chromogranin A regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release–inhibitory) mechanisms. Chromogranin A also plays a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathway by virtue of their ability to aggregate in the low-pH, high-calcium environment of the trans-Golgi network. Therefore, Chromogranin A represents a specific marker of neuroendocrine cells and tumors including pheochromocytomas.
Catalog #C5069-96H
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry: 1:100-1:200
Optimal dilutions to be determined by the researcher.
HybridomaDerived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Chromogranin A protein.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No9E16
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human Chromogranin A (19-131aa) purified from E. coli. Molecular Weight: 51kD.
SpecificityRecognizes human Chromogranin A.
Species crossreactivityMouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links