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You are here:Home » Antibodies » Abs to Chromogranin » Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid Secretory Protein 1, Pituitary Secretory Protein I, Vasostatin, SPI)

Anti -Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid Secretory Protein 1,
Pituitary Secretory Protein I, Vasostatin, SPI)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant IH
The prohormone chromogranin A (CgA) is a member of the chromogranin/secretogranin protein family of regulated secretory proteins, which are widely distributed in secretory granules of endocrine, neuroendocrine, and neuronal cells. It is required for the formation of dense-core secretory granules and hormone sequestration in sympathoadrenal chromaffin cells. It functions as prohormones, giving rise to bioactive peptides, vasostatin, pancreastatin, and parastatin as a result of post-translational proteolytic processing. Peptides derived from chromogranin A have autocrine, paracrine, and endocrine activities. It also inhibit secretion of proopiomelanocortin hormone. Catestatin, another fragment of chromogranin A, inhibits the release of catecholamines from sympathoadrenal chromaffin cells by blocking the neuronal nicotinic cholinergic receptor, which is the physiologic trigger for secretion. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. It maps to 14q32 region of human chromosome.
Catalog #C5069-97E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (formalin fixed paraffin embedded): 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlPancreas
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No11E126
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenRecombinant corresponding to protein encoding human Chromogranin A. Cellular Localization: Cytoplasmic.
SpecificityRecognizes human Chromogranin A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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