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You are here:Home » Antibodies » Abs to MHC » Anti -CIITA, CT (Class II Major Histocompatibility Complex Transactivator, Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator, NLRA)

Anti -CIITA, CT (Class II Major Histocompatibility Complex Transactivator, Class II Trans
Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator, NLRA)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified E IP
CIITA regulates basal and interferon induced MHC-II transcription through interactions with multiple proteins including transcription factors, chromatin modifying enzymes and components of the basal transcription machinery. CIITA regulates MHC-II expression principally in immune cells, but can also affect their expression in endothelial and fibroblast cells.
Catalog #C5072-61D
Mutations in this gene have been associated with bare lymphocyte syndrome type II, which leads to an extreme susceptibility to viral, bacterial and fungal infections. Silencing of CIITA through epigenetic mechanisms also has a major impact on MHC-II expression in tumor cells and can facilitate immune escape.
ApplicationsSuitable for use in ELISA and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by Ion Exchange chromatography.
ImmunogenSynthetic peptide corresponding to a region near the C-terminal end (aa726-742) of the human CIITA gene conjugated to KLH.
SpecificityRecognizes human Class II transactivator (CIITA).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMHC Class II Transactivator Type III, NLR Family Acid Domain Containing, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Acid Domain Containing


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