| Ciprofloxacin Hydrochloride is a high activity fluoroquinolone antibiotic effective against a broad spectrum of gram positive and negative bacteria such as pseudomonas, salmonella, streptococcus and staphylococcus. Effective against mycoplasma (12 days). |
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| Catalog # | C5074 |
| Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. |
| The bactericidal action of ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA. |
| Ciprofloxacin has been shown to be active against most strains of the following organisms | |
| Gram-Positive Bacteria | Enterococcus faecalis (Many strains are only moderately susceptible); Staphylococcus haemolyticus; Staphylococcus hominis; Staphylococcus saprophyticus; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae; Streptococcus pyogenes. |
| Gram-Negative Bacteria | Acinetobacter calcoaceticus subs. anitratus; Acinetobacter calcoaceticus subs. Iwoffi; Aeromonas caviae; Aeromonas hydrophila; Brucella melitensis; Campylobacter coli; Campylobacter jejuni; Citrobacter diversus; Citrobacter freundii; Edwardsiella tarda; Enterobacter aerogenes; Enterobacter cloacae; Escherichia coli; Haemophilus ducreyi; Haemophilus influenzae; Haemophilus parainfluenzae; Klebsiella oxytoca; Klebsiella pneumoniae; Legionella pneumophila; Moraxella (Branhamella) catarrhalis; Morganella morganii; Neisseria gonorrhoeae; Neisseria meningitidis; Pasteurella multocida; Proteus mirabilis; Proteus vulgaris; Providencia rettgeri; Providencia stuartii; Pseudomonas aeruginosa; Salmonella enteritidis; Salmonella typhi; Serratia marcescens; Shigella flexneri; Shigella sonnei; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Yersinia enterocolitica. |
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| Other Organisms: Chlamydia trachomatis (only moderately susceptible); Mycobacterium tuberculosis (only moderately susceptible). |
| Also Available | C5074: Ciprofloxacin Hydrochloride |
| C5075: Ciprofloxacin Hydrochloride 10mg/ml |
| CAS Number | 86393-32-0 |
| Molecular Formula | C17H18FN3O3•HCl•H2O |
| Molecular Weight | 385.8 |
| Purity | 98-102% |
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| Form | Supplied as a lyophilized powder. |
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| Appearance | Faintly yellowish to light yellow crystalline powder |
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| Solubility | |
| Water | 3.5g/dL |
| Methanol | 0.21g/dL |
| Acetic acid | 0.14g/dL |
| Ethanol | 0.016g/dL |
| In water and 0.1M NaOH | Solutions are stable to hydrolysis for 16 hrs. at 90°C. |
| In 0.1M HCl | Displays slight decarboxylation. |
| Turbidity can be cleared by heat to 30-50°C |
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| pH | 3.0-4.5 (The pH for 0.2% infusion solutions is 3.5-4.6). |
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| Ash | 0.10% |
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| Heavy Metals | 0.002% |
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| Working Concentration | |
| Effective at low concentrations (10ug/ml) in water and buffered media. |
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| Storage and Stability | |
| Store powder at -20°C. Reconstitute with suitable solvent. Aliquot and store at -20°C. Solutions should be protected from light. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Alternate names | 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid |
