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You are here:Home » Biochemicals » Biochem-Antibiotics » Ciprofloxacin Hydrochloride

Ciprofloxacin Hydrochloride

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Specifications

Ciprofloxacin Hydrochloride is a high activity fluoroquinolone antibiotic effective against a broad spectrum of gram positive and negative bacteria such as pseudomonas, salmonella, streptococcus and staphylococcus. Effective against mycoplasma (12 days).
Catalog #C5074
Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position.
The bactericidal action of ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA.
Ciprofloxacin has been shown to be active against most strains of the following organisms
Gram-Positive Bacteria Enterococcus faecalis (Many strains are only moderately susceptible); Staphylococcus haemolyticus; Staphylococcus hominis; Staphylococcus saprophyticus; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae; Streptococcus pyogenes.
Gram-Negative Bacteria Acinetobacter calcoaceticus subs. anitratus; Acinetobacter calcoaceticus subs. Iwoffi; Aeromonas caviae; Aeromonas hydrophila; Brucella melitensis; Campylobacter coli; Campylobacter jejuni; Citrobacter diversus; Citrobacter freundii; Edwardsiella tarda; Enterobacter aerogenes; Enterobacter cloacae; Escherichia coli; Haemophilus ducreyi; Haemophilus influenzae; Haemophilus parainfluenzae; Klebsiella oxytoca; Klebsiella pneumoniae; Legionella pneumophila; Moraxella (Branhamella) catarrhalis; Morganella morganii; Neisseria gonorrhoeae; Neisseria meningitidis; Pasteurella multocida; Proteus mirabilis; Proteus vulgaris; Providencia rettgeri; Providencia stuartii; Pseudomonas aeruginosa; Salmonella enteritidis; Salmonella typhi; Serratia marcescens; Shigella flexneri; Shigella sonnei; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Yersinia enterocolitica.
Other Organisms: Chlamydia trachomatis (only moderately susceptible); Mycobacterium tuberculosis (only moderately susceptible).
Also AvailableC5074: Ciprofloxacin Hydrochloride
C5075: Ciprofloxacin Hydrochloride 10mg/ml
CAS Number86393-32-0
Molecular FormulaC17H18FN3O3•HCl•H2O
Molecular Weight385.8
Purity98-102%
FormSupplied as a lyophilized powder.
AppearanceFaintly yellowish to light yellow crystalline powder
Solubility
Water3.5g/dL
Methanol0.21g/dL
Acetic acid0.14g/dL
Ethanol0.016g/dL
In water and 0.1M NaOHSolutions are stable to hydrolysis for 16 hrs. at 90°C.
In 0.1M HClDisplays slight decarboxylation.
Turbidity can be cleared by heat to 30-50°C
pH3.0-4.5 (The pH for 0.2% infusion solutions is 3.5-4.6).
Ash0.10%
Heavy Metals0.002%
Working Concentration
Effective at low concentrations (10ug/ml) in water and buffered media.
Storage and Stability
Store powder at -20°C. Reconstitute with suitable solvent. Aliquot and store at -20°C. Solutions should be protected from light. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Alternate names1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid


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