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You are here:Home » Antibodies » Antibodies-Autophagy » Anti -CIS1, ID (Autophagy-related Protein 31, CIK1 Suppressor Protein 1, Protein CIS1, ATG31, YDR022C, PZD196, YD9335.08c)

Anti -CIS1, ID (Autophagy-related Protein 31, CIK1 Suppressor Protein 1, Protein CIS1,
ATG31, YDR022C, PZD196, YD9335.08c)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous aa long sequence at the C-terminus that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. CIS is the first recognized and one of the well-studied members of the SOCS family. It is 258aa long with short N-terminus and shares sequence similarity with SOCS-2. CIS mRNA normally presents at very low levels in different tissues; however, its level is rapidly increased upon stimulation with IL-1, IL-4, IL-6, IL-7, IL-12, IL-13, EPO, IFNg, TNFa, prolactin, GH, and leptin. CIS inhibits signaling by binding to activated cytokine receptors; for example, CIS binds to pY401 of the EPO receptor and to pY985/pY1077 motifs of the leptin receptor. In addition, recent findings demonstrate that its C-terminal region residue Y253 is critical for CIS functioning.
Catalog #C5500-03B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to internal sequence of human CIS-1.
SpecificityRecognizes human CIS-1. Species Crossreactivity: rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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