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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -CITED 2 (Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2, MRG1, P35SRJ)

Anti -CITED 2 (Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal
domain 2, MRG1, P35SRJ)


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Clone Host Grade Applications
Monoclonal Rat Affinity Purified B
Cited-2 is a 270aa protein that functions by binding to the CH1 region of CREB binding protein (CBP)/p300. This binding interferes with certain transcription factors like HIF1a and STAT2 blocking their ability to bind and interact with CBP/p300. Cited-2 knockout mice die due to defects in heart and neural tube development. Mutations in Cited-2 have been reported in patients with congenital heart defects. It appears Cited-2 modulates apoptosis by a p53 independent pathway whereby the details still need to be elucidated.
Catalog #C5675-06D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No11n47
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa1-269 from mouse Cited-2 expressed in E. coli (O35740).
SpecificityRecognizes mouse Cited-2. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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