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You are here:Home » Antibodies » Abs to Collagen » Anti -CLAC-P, NC2-1 Region (Collagen alpha-1(XXV) Chain, Alzheimer Disease Amyloid-associated Protein, AMY, COL25A1)

Anti -CLAC-P, NC2-1 Region (Collagen alpha-1(XXV) Chain, Alzheimer Disease
Amyloid-associated Protein, AMY, COL25A1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100kD polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.
Catalog #C5819-50D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P.
SpecificityRecognizes human CLAC-P, NC2-1 region. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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