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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CLAN (NLR Family CARD Domain-containing Protein 4, CARD, LRR, and NACHT-containing Protein, Clan Protein, Caspase Recruitment Domain-containing Protein 12, Ice Protease-activating Factor, Ipaf, NLRC4, CARD12, CLAN1, IPAF, UNQ6189/PRO20215)

Anti -CLAN (NLR Family CARD Domain-containing Protein 4, CARD, LRR, and NACHT-containing
Protein, Clan Protein, Caspase Recruitment Domain-containing Protein 12, Ice
Protease-activating Factor, Ipaf, NLRC4, CARD12, CLAN1, IPAF, UNQ6189/PRO20215)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IC IF
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family. Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner. Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.
Catalog #C5820-01E
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 10ug/ml
Western Blot: 0.5-2ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman peripheral blood leukocyte (PBL) cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human CLAN.
SpecificityRecognizes human CLAN.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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