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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Clara Cell Protein (CC16, CC10, Uteroglobin, Urinary Protein 1, Clara Cell Secretory Protein, CCSP)

Anti -Clara Cell Protein (CC16, CC10, Uteroglobin, Urinary Protein 1, Clara Cell Secretory
Protein, CCSP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as a number of other immunomodulatory features, including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
Catalog #C5828-03
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1:2000 dilution detected CCSP in paraffin-embedded mouse lung sections. Paraffin-embedded adult mouse lung sections were stained with C5828-03. Proteins were visualized using a IgG (Biotin) goat anti-rabbit secondary antibody and an ABC detection system.
Western Blot: Reported to detect CCSP in mouse lung nuclear extracts.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot Determined
FormSupplied as a liquid, 0.05% sodium azide, 30% glycerol
PuritySerum
ImmunogenSynthetic peptide corresponding to aa45-68 of mouse Clara Cell Secretory Protein, conjugated to KLH.
SpecificityRecognizes mouse Clara Cell Secretory Protein, Mr 10kD.
Species CrossreactivityRat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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