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You are here:Home » Antibodies » Abs to Claudin » Anti -Claudin 1, CT (Claudin-1, Senescence-associated Epithelial Membrane Protein, CLD1, SEMP1, CLDN1, UNQ481/PRO944)

Anti -Claudin 1, CT (Claudin-1, Senescence-associated Epithelial Membrane Protein, CLD1,
SEMP1, CLDN1, UNQ481/PRO944)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Catalog #C5838-02H
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human Claudin 1 at C-terminal.
SpecificityRecognizes human Claudin 1. Species sequence homology: Canine, monkey, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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