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You are here:Home » Antibodies » Antibodies-Claudin » Anti -Claudin 1 (Claudin-1, CLD1, CLDN1, ILVASC, Senescence-associated Epithelial Membrane Protein, SEMP1, UNQ481/PRO944)

Anti -Claudin 1 (Claudin-1, CLD1, CLDN1, ILVASC, Senescence-associated Epithelial Membrane
Protein, SEMP1, UNQ481/PRO944)


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Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Claudin1, a 22kD integral membrane protein, is a member of Claudin family. It is a critical component of tight junction strands and consists of 2 extracellullar loops, 4 hydrophobic transmembrane domains and a cytoplasmic tail containing PDZ-binding motif. Studies on MDCK cells and knock-out mice have revealed that Claudin-1 plays a vital role in forming tight junctions that serve as a physical barrier preventing free passage of solutes and water through the paracellular spaces. Its role has also been suggested in beta-catenin-Tcf/LEF signaling pathway. Mutations in Claudin-1 have been strongly suggested in NISCH syndrome. Northern-Blot analysis detected a ubiquitous expression of Claudin-1 with highest in liver and kidney.
Catalog #C5838-02J
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:100-1:200
Optimal dilutions to be determined by the researcher.
Positive ControlBreast carcinoma, skin
Cellular Localization
Cytoplasmic and cell membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
ImmunogenSynthetic peptide corresponding to C-terminal of human Claudin 1.
SpecificityRecognizes human Claudin 1. Species Crossreactivity: mouse, canine, rat, and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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