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You are here:Home » Antibodies » Abs to Claudin » Anti -Claudin 2 (Claudin-2, CLDN2, PSEC0059, SP82, UNQ705/PRO1356)

Anti -Claudin 2 (Claudin-2, CLDN2, PSEC0059, SP82, UNQ705/PRO1356)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Claudin-2, a 22kD integral membrane protein, is a member of Claudin family and was discovered along with Claudin-1. It is also a vital component of tight junction strands and consists of 2 extracellullar loops, 4 hydrophobic transmembrane domains and a cytoplasmic tail containing PDZ-binding motif. Studies on MDCK cells suggest that Claudin-2 determines the overall transepithelial membrane resistance properties and increases conductance by forming cation-selective channels in tight junction of epithelial cells. Claudin-2 is differentially expressed in the intestine and has been suggested to be involved in the regulation of intestinal cell monolayer barrier function through immune modulators such as interleukins.
Catalog #C5838-17A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:100-1:200
Optimal dilutions to be determined by the researcher.
Positive ControlOvarian carcinoma, tonsil
Cellular Localization
Cytoplasmic and cell membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to C-terminal of human Claudin 2.
SpecificityRecognizes human Claudin 2. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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