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You are here:Home » Antibodies » Antibodies-Claudin » Anti -Claudin 4 (CLDN4)

Anti -Claudin 4 (CLDN4)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Claudin 4 is a multipass membrane protein in the claudin family of tight junction proteins. Claudin 4 is a 209 amino acid molecule with four transmembrane segments. It is preferentially expressed in intestinal mucosa epithelium and is involved in epithelial tissue development. It is also upregulated in several carcinomas. Phosphorylation of claudin 4 regulates paracellular epithelial permeability. Human claudin 4 shares 83% aa sequence identity with mouse and rat claudin 4.
Catalog #C5838-35C
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 25ug/10e6 cells. Validated for use with PC-3 human prostate cancer cell line.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
Clone No7H177
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to aa1-209 from human Claudin 4 expressed in NS0 cells (NP_001296).
Species Sequence HomologyMouse and rat, 83%
SpecificityRecognizes human Claudin 4. Recognizes an epitope in the first extracellular loop (between aa 29-81). Stains human Claudin 4 transfectants but not irrelevant transfectants.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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