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You are here:Home » Antibodies » Abs to Claudin » Anti -Claudin 5 (Claudin-5, CLDN5, AWAL, BEC1, CPETRL1, Transmembrane Protein Deleted in VCFS, TMDVCF, TMVCF)

Anti -Claudin 5 (Claudin-5, CLDN5, AWAL, BEC1, CPETRL1, Transmembrane Protein Deleted in
VCFS, TMDVCF, TMVCF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Claudin-5 is a member of the claudin family. It is a transmembrane protein reported to be a major cell adhesion molecule of tight junctions in brain endothelial cells. Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (BBB). Claudin-5 is involved in the function of the blood-brain barrier (BBB) and plays a major role in tight junction-specific obliteration of the intercellular space. Mutations in this gene have been found in patients with velocardiofacial syndrome. It is expressed ubiquitously, even in organs lacking epithelial tissues such as the brain, skeletal muscle, and spleen.
Catalog #C5838-47C
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlLung
Cellular Localization
Cytoplasmic and cell membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to C-terminal of human Claudin 5.
SpecificityRecognizes human Claudin 5. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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