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Anti -CNG3 (Cyclic Nucleotide-Gated Channels 3)
Anti -CNG3 (Cyclic Nucleotide-Gated Channels 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated a and b subunits. Several CNG a-subunits (CNG alpha 1-3) & beta subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves, whereas, b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a, and b subunits. | | | Catalog # | C6005-04 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1-10ug/ml using ECL. | | ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml. | | Optimal dilutions to be determined by the researcher. | | Control Peptide | C6005-05: CNG3, Rat (Cyclic Nucleotide-Gated Channels 3) Control Peptide | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | 1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 40% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | A 14 amino acid peptide sequence near N-terminus of rat/mouse CNG3 (KLH). | | Specificity | Recognizes rat CNG3. Species sequence homology: chicken, 83%; human, 75%. No significant sequence homology is detected with other CNGs. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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