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You are here:Home » Antibodies » Abs to Ion Channel » Anti -CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNGa2, CCNC1)

Anti -CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNGa2, CCNC1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels. 1 The CNG channels are non-selective cation channels facilitating the influx of Na +and Ca 2+ ions, following activation by intracellular cyclic nucleotides. 2In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. The native CNG channels are composed of alpha and beta subunits in a tetrameric configuration. To date, four types of the alpha subunits (CNGA1-4) and two beta subunits (CNGB1, CNGB3) have been characterized. 3-4 Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains but, are also modulated by other factors including phosphorylation and calmodulin. 5In a heterologous expression system, only the alpha subunits are capable of forming functional homomeric channels. CNG ion channels are essential in visual and olfactory signal transduction. The CNGA3 channel is primarily expressed in cone photoreceptors where it participates in light transduction (daylight and color vision). CNG channels expression was also found in the hippocampus, cortex, Purkinje cells and other neural derived tissues. CNGA3 was also detected in kidney, heart, brain and sperm, where it was thought to have an important role in the control of sperm motility and fertility. However, CNGA3-deficient mice were shown to be as fertile and produce at normal rate as wild types. 6
Catalog #C6005-10
Applications  
Western blotting of rat brain membranes:  
1. Anti-CNGA3 antibody (1:200)
2. Anti-CNGA3 antibody, preincubated with the control peptide antigen.
Control antigen included
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified
ImmunogenPeptide (C)GHGFSPDRENSEDASKAD, corresponding to amino acid residues 594-611 of rat CNGA3 (accession number Q9QWN7).
SpecificityHomology with other species
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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