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You are here:Home » Antibodies » Antibodies-Collagen » Anti -Collagen Type II

Anti -Collagen Type II


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH
Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody CIIC1 has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.
Suitable for use in Functional Studies, Immunohistochemistry, and Immunoassays. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (frozen and paraffin): 1:10
Optimal dilutions to be determined by the researcher.
Catalog #C7510-20D
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No9G172
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.1% BSA.
ImmunogenMouse collagen type II.
SpecificityRecognizes the J1 epitope (triple helical position 551-564) of collagen type II. Species crossreactivity: rat, bovine, chicken, human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCII, J1 epitope

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