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You are here:Home » Antibodies » Abs to Collagen » Anti -Collagen Type IV (Arresten, ASLN, ATS, CA54, Canstatin, COL4A1, COL4A2, Collagen Alpha 1(IV) Chain, Collagen Alpha 2(IV) Chain, Collagen IV Alpha 1 Polypeptide, Collagen IV Alpha 2 Polypeptide, Collagen of Basement Membrane Alpha 1 Chain, Collagen of Base

Anti -Collagen Type IV (Arresten, ASLN, ATS, CA54, Canstatin, COL4A1, COL4A2, Collagen
Alpha 1(IV) Chain, Collagen Alpha 2(IV) Chain, Collagen IV Alpha 1 Polypeptide, Collagen
IV Alpha 2 Polypeptide, Collagen of Basement Membrane Alpha 1 Chain, Collagen of Base

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E IH
Catalog #C7510-50D
Collagen IV is a major constituent of the basement membranes along with laminins and enactins. It is composed of a1(IV) chain and a2(IV) chain in 21 ratio . It can form insoluble fibers with high tensile strength. Antibody to collagen IV is useful in detecting the loss of parts of basement membrane in carcinomas.
Excellent for the staining of routine formalin-fixed, paraffinembedded tissues.
ApplicationsImmunohistology (Formalin/paraffin): (Use Ab at 1:50-1:100 for 30 min at RT) (Staining of formalin/paraffin tissues is enhanced by digestion of tissue sections with Protease XXV at 1mg/ml PBS for 5 minutes at 37°C.
Positive Control Skin
Cellular Localization Basement membrane
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1+IgG1
Clone No5G84
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid with 0.09% sodium azide.
PurityCulture supernatant
ImmunogenHuman glomeruli
SpecificityHighly specific to type IV collagen. In kidney, Ab reacts with glomerular and tubular basement membranes, parts of mesangial matrix and the Bowmanís capsule. It also reacts with basal lamina of capillaries as well as basement membranes in a variety of tissues. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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