Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications Polyclonal Sheep Purified

C1r is a plasma protein and forms part of the C1 pentamer, the first component of the classical complement pathway. The C1r dimer binds to two C1s molecules in a Ca2+-dependent manner. This tetramer then binds to C1q to form the C1 pentamer. C1r is a serine protease and on the binding of C1 to an immune complex, C1r self activates. Activated C1r (CTr) in turn activates C1s, the other serine protease component of C1. Activated C1 in turn activates C4 and C4bC2 and is inhibited by C1-inactivator.Normal plasma concentrations of C1r are around 34 mg/L. Unactivated C1r consists of a single polypeptide chain of MW 173kDa. When activated it is cleaved to two polypeptide chains linked by disulfide bonds, the A chain (55kDa) and B chain (31kDa).
Catalog #	C7850-07A
Applications	Suitable for use in RID. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Sheep
Source	Human
Concentration	As reported
Form	Supplied as a liquid in GBS, pH 7.2, 0.1% sodium azide, 0.1% EACA, 0.01% benzamidine,1mM EDTA.
Purity	Purified
Immunogen	Human C1r prepared form human plasma.
Specificity	This product gives a single arc when tested by IEP against fresh human plasma. Identity has been confirmed by double diffusion (Ouchterlony) vs fresh human plasma and a known anti-human C1r. Species Crossreactivity: Crossreacts with Human. Not yet tested in other species.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	C1R, Complement Component 1 r Subcomponent, Complement C1r subcomponent precursor