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C7850-08H Mouse Anti-Complement 1s (Complement Component 1 s subcomponent, Basic proline-rich peptide IB-1, C1 esterase, Complement C1s subcomponent precursor)

Specifications
Clone Type
Polyclonal
Host
Mouse
Source
Human
Isotype
IgG
Grade
Purified
Applications
WB
Crossreactivity
Hu
Accession #
NP_001725.1
Shipping Temp
Blue Ice
Storage Temp
-20°C

C1s proenzyme is a glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single chain polypeptide of 688aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2kD) and B chain (27.7kD). The Ca dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
C1S (NP_001725.1, 1-688aa) full-length human protein.
Form
Supplied as a liquid in PBS, pH 7.2.
Purity
Purified.
Specificity
Recognizes human C1S.
Conjugates
Pricing
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