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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C3

Anti -Complement C3

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified E B
Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the alpha chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement- pathway C3/C5 convertase. C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.
Catalog #C7850-10B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1903-80: IgY, H&L, X-Adsorbed, 12nm (Gold) Pab Dk x Ch
I1903-80A: IgY, H&L, X-Adsorbed, 18nm (Gold) Pab Dk x Ch
I1903-80B: IgY, H&L, X-Adsorbed, 6nm (Gold) Pab Dk x Ch
I1906: IgY Pab Rb x Ch
I1906-01: IgY, Fc (HRP) Pab Gt x Ch
I1906-10: IgY (HRP) Pab Rb x Ch
I1906-12: IgY (FITC) Pab Rb x Ch
I1906-14: IgY (AP) Pab Rb x Ch
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant human Complement C3, aa1-1663, GI #4557385.
SpecificityRecognizes human Complement C3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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