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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C3, Human

Anti -Complement C3, Human

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
Catalog #C7850-10R
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:10-1:100
Western Blot: 1:10-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J444
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
PurityPurified
ImmunogenHuman C3/C3a. Cellular Localization: Secreted
SpecificityRecognzies human Complement C3 at ~187kD. Reacts with both intact C3 and an epitope on C3a.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesComplement component 3, ASP, Complement C3 precursor, CPAMD1, Acylation Stimulating Protein Cleavage Product


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