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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B

The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3a is a mediator of local inflammatory processes. C3a does induce smooth muscle contraction, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes.
Catalog #	C7850-13B
Applications	Can be used for Western Blot and immunoassays.
Recommended Dilution	Western Blot: 1:10
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	6A526
Host	Mouse
Source	Human
Concentration	~0.1mg/ml
Form	Supplied as a liquid in PBS, containing 0.02% sodium azide and 0.1% BSA.
Purity	Purified IgG
Specificity	Reacts with an epitope on C3a. Reacts both with intact C3 as with C3a.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.