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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1)

Anti -Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein
Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH FC
C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
Catalog #C7850-14N
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunohistochemistry (frozen), and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10B387
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in borate buffered saline, pH 8.4, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman C3 from normal serum.
SpecificityRecognizes human complement component 3c (C3c) at ~135kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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