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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C3, C3d (Complement C3d Fragment, Complement Component C3d, C3/C3d, Complement Component 3, Complement Factor 3, CPAMD1)

Anti -Complement C3, C3d (Complement C3d Fragment, Complement Component C3d, C3/C3d,
Complement Component 3, Complement Factor 3, CPAMD1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH FC
Human complement component 3d (C3d) neoantigen is a 33kD polypeptide fragment generated over the course of complement activation in which where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
Catalog #C7850-14Y
ApplicationsSuitable for use in ELISA, Flow Cytometry, and Immunohistochemistry (frozen). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10B389
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in borate buffered saline, pH8.2-8.4, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified human C3d (neoantigen).
SpecificityRecognizes human complement component 3d (C3d) neoantigen at ~33kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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