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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C5 (Complement Component C5, Anaphylatoxin C5a Analog, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 4, CPAMD4)

Anti -Complement C5 (Complement Component C5, Anaphylatoxin C5a Analog, C3 and PZP-like
alpha-2-macroglobulin Domain-containing Protein 4, CPAMD4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
C5 is synthesized in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kD glycoprotein consisting of disulfide-linked alpha chain (115kD) and beta chain (75kD). It occurs in plasma at about 75mg/ml. C5 is activated, via either the classical or alternative complement pathway, by protoelytic cleavage of C5a (11.5kD) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b, initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.
Catalog #C7850-24R
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 10mM sodium phosphate, 0.15M sodium chloride, pH 7.2, 0.05% sodium azide.
PurityPurified by affinity chromatography. > 95% by SDS-PAGE.
ImmunogenPurified human Complement C5
SpecificityRecognizes human Complement C5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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