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Anti -Complement C5 (Complement Component C5, Anaphylatoxin C5a Analog, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 4, CPAMD4)
Anti -Complement C5 (Complement Component C5, Anaphylatoxin C5a Analog, C3 and PZP-like
alpha-2-macroglobulin Domain-containing Protein 4, CPAMD4)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E |
|
| C5 is synthesized in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kD glycoprotein consisting of disulfide-linked alpha chain (115kD) and beta chain (75kD). It occurs in plasma at about 75mg/ml. C5 is activated, via either the classical or alternative complement pathway, by protoelytic cleavage of C5a (11.5kD) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b, initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens. | | | Catalog # | C7850-24R | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 10mM sodium phosphate, 0.15M sodium chloride, pH 7.2, 0.05% sodium azide. | | Purity | Purified by affinity chromatography. > 95% by SDS-PAGE. | | Immunogen | Purified human Complement C5 | | Specificity | Recognizes human Complement C5. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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