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You are here:Home » Antibodies » Abs to Complement » Anti -C5b-9 Terminal Complement Complex (TCC)

Anti -C5b-9 Terminal Complement Complex (TCC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH
C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual nativecomponents from which they are formed.
Catalog #C7850-26
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Not suitable for Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: Frozen and paraffin sections
Optimal dilutions to be determined by the researcher.
Culture MediumRPMI 1640 with 10% fetal calf serum
HybridomaX63.Ag8.653 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No9B1
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified C5b-9
SpecificityRecognizes a neoepitope exposed on human C9 when incorporated into the TCC. Binds both membrane-bound MAC and fluid-phase SC5b-9 complexes. Species Crossreativity: porcine, baboon and equine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTerminal Complement Complex (TCC)


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