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Anti -C5b-9 Terminal Complement Complex (TCC)
Anti -C5b-9 Terminal Complement Complex (TCC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E |
|
| C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and is directed against a neoepitope exposed on C9 when incorporated into the TCC (1,2). | | | Catalog # | C7850-27B | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2ak | | Clone No | 13A96 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 0.01M phosphate buffer, pH 7.4, 0.14M NaCl and 15mM sodium azide. | | Purity | Purified | | Immunogen | Purified C5b-9 | | Specificity | Recognizes human C5b-9. Species Crossreactivity: Porcine, baboon, equine TCC, and both membrane-bound MAC and fluid-phase SC5b-9 complexes. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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