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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH FC

Human C9 is a soluble glycoprotein of 61kD. It is the last component in the assembly of the membrane attack complex (MAC). When the complement is activated on target membranes, multiple copies of C9 bind to the C5b-8 complex and assemble the barrel-shaped pore which causes cell lysis. The conformation of C9 changes from globular to a tubular form. The binding of C9 to C5b-8 plays a key role in the function of C9.
Applications:
Suitable for use in ELISA, Western Blot, Flow Cytometry, Immunohistochemistry, and inhibition of C9 binding to C5b-8. Other applications not tested.
Catalog #	C7850-51B
Recommended Dilution	Flow Cytometry: 1:10
	Western Blot: 1:10
	Immunohistochemistry (frozen and paraffin): 1:10
	Optimal dilutions to be determined by the researcher.
Storage and Stability	For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
CAS Number	N/A
Clone Type	Monoclonal
Isotype	IgG1
Clone No	9G177
Host	Mouse
Source	Human
Concentration	~0.1mg/ml
Form	Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
Purity	Purified
Immunogen	Human C9. Epitope: C-terminal region.
Specificity	Recognizes human Complement C9 at~61kD.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	C-term