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You are here:Home » Antibodies » Antibodies-Complement » Anti -Complement Factor B (C3/C5 Convertase, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD, Complement Factor B Ba Fragment)

Anti -Complement Factor B (C3/C5 Convertase, Glycine-rich beta Glycoprotein, GBG, PBF2,
Properdin Factor B, CFB, BF, BFD, Complement Factor B Ba Fragment)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP
Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764aa (MW 90kD), including a leader peptide of 25aa. Factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound factor B resulting in the release of Ba (MW 33kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals. In addition to complement activation, factor B fragments participate in other immunological functions.
Catalog #C7850-60M
ApplicationsSuitable for use in Western Blot, ELISA and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No13A38
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
SpecificityRecognizes human complement factor B/Ba.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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