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You are here:Home » Antibodies » Abs to Complement » Anti -CFHR4 (Complement Factor H-related Protein 4, FHR-4, H Factor-like Protein 4, H-Factor-like 4, H36, CFHL, CFHL4, CFHL4P, CFHR4P, FHR4, HFL4)

Anti -CFHR4 (Complement Factor H-related Protein 4, FHR-4, H Factor-like Protein 4,
H-Factor-like 4, H36, CFHL, CFHL4, CFHL4P, CFHR4P, FHR4, HFL4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B
CFHR4 (Complement Factor H-related protein 4; also FHR4B) is a 45kD glycoprotein member of the factor H-related protein family. It is synthesized by hepatocytes and circulates in plasma. FHR4(B) binds to C3b and C3d. It also binds to native (pentameric) C-reactive protein (pCRP), and is suggested to promote pCRP binding to necrotic cells surfaces, thus promoting cell clearance. Mature human FHR4B is 312aa in length. It contains five Sushi/SCR domains, the first of which (aa23-85) is associated with pCRP binding. There is a circulating, 86kD alternative splice form termed FHR4A that shows an insertion of 247aa after Asp92. This is considered the dominant isoform, and appears to show the same activity as FHR4B. Over (aa41 -331, human FHR4B shares 61% aa identity with a related molecule found in rat.
Catalog #C7850-87
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionDirect ELISA: 0.5-1ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to human CFHR4 expressed in Sf21 (AAH74957).
SpecificityRecognizes human CFHR4. Species Crossreactivity: recombinant, human CFHR1, recombinant, human CFHR2 and recombinant, human CFHR5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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