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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -COMT (Catechol-O-methyltransferase)

Anti -COMT (Catechol-O-methyltransferase)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.
Catalog #C7851-71
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No5E45
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, before the addition of glycerol to 40%.
PurityPurified by affinity chromatography.
ImmunogenFull-length recombinant COMT (aa1-183) with GST tag.
MW weight of tag26kD.
SpecificityRecognizes human COMT at 45.76kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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