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Concanamycin A (Folimycin, Antibiotic TAN 1323B)
Concanamycin A (Folimycin, Antibiotic TAN 1323B)
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| Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has has been shown to act as a potent and specific vacuolar-APTase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. | | | Catalog # | C7852-20 | | Purity | >99% by HPLC | | Solubility | Soluble in ethanol, methanol, DMF or DMSO | | Related to | Bafilomycin A1, Bafilomycin B1, Bafilomycin C1 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 80890-47-7 | | Molecular Formula | C46H75NO14 | | Molecular Weight | 866.09 | | Form | Supplied as a lyophilized powder. | | | Source | Streptomyces sp. | | | Purity | ~90% by HPLC | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Folimycin, Antibiotic TAN 1323B |
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