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You are here:Home » Biochemicals » Biochem-Antibiotics » Concanamycin A (Folimycin, Antibiotic TAN 1323B)

Concanamycin A (Folimycin, Antibiotic TAN 1323B)


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Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has has been shown to act as a potent and specific vacuolar-APTase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
Catalog #C7852-20
Purity >99% by HPLC
Solubility Soluble in ethanol, methanol, DMF or DMSO
Related to Bafilomycin A1, Bafilomycin B1, Bafilomycin C1
Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number80890-47-7
Molecular FormulaC46H75NO14
Molecular Weight866.09
FormSupplied as a lyophilized powder.
SourceStreptomyces sp.
Purity~90% by HPLC
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFolimycin, Antibiotic TAN 1323B

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