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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 26 (CX26, Gap Junction Beta 2 Protein, CXB-2)

Anti -Connexin 26 (CX26, Gap Junction Beta 2 Protein, CXB-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Intercellular communication through gap junctions plays an important role in a variety of cellular processes including
homeostasis, morphogenesis, cell differentiation, and growth control. Gap junctions are transmembrane channels that
serve to directly link neighboring cells by mediating the exchange of low-MW <1200 kD metabolites, ions, and second messengers. Gap junctions are formed by the interaction of hemichannels (connexons) on adjacent cells. The
connexon itself is composed of a hexameric assembly of connexin proteins. Connexins are highly homologous proteins
encoded by a multigene family. The connexins exhibit similar structural features, which include a cytoplasmic amino terminal
region, four transmembrane domains, two extracellular loops, and a carboxy-terminal cytoplasmic tail of varying length.
Catalog #C7853-04
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA (Immunogen): 0.1-1.0ug/ml
Immunohistochemistry (Rat): 10-20ug/ml
Western Blot (Mouse and Rat): 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 13aa derived from the C-terminus of the mouse Connexin 26 protein. This mouse sequence differs from the rat sequence by a single aa and from the human sequence by two (non-consecutive) amino acids.
SpecificityRecognizes mouse Connexin 26. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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