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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin-26 (GJB2, Gap Junction beta-2 Protein, Cx26)

Anti -Connexin-26 (GJB2, Gap Junction beta-2 Protein, Cx26)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Immunohistochemical staining of human cochlear cells demonstrated high levels of GJB2 expression. Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Catalog #C7853-04B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.01-0.03ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse Brain lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to YLLIRYCSGKSKKP, from the C-terminus of the protein sequence according to NP_003995.2.
SpecificityRecognizes mouse Connexin 26. Species sequence homology: human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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