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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B IP

Intercellular communication through gap junctions plays an important role in a variety of cellular processes including homeostasis, morphogenesis, cell differentiation, and growth control. (1–4) Gap junctions are transmembrane channels that directly link neighboring cells by mediating the exchange of low-molecular weight (<1200kD) metabolites, ions, and second messengers. Gap junctions are formed by the interaction of hemichannels (connexons) on adjacent cells. Connexons are hexameric assemblies of connexin proteins. At least 14 connexin genes are known.
Catalog #	C7855-17
Applications	Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution	ELISA: 0.1-1.0ug/ml
	Western Blot: 1ug/ml
	Immunoprecipitation: 2-3ug/ IP
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Mouse
Concentration	~0.125mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Peptide corresponding to a sequence from the C-terminus of rat and mouse Connexin 36 (Cx36). This sequence differs from the human Cx36 protein by a single amino acid.
Specificity	Recognizes mouse Cx36 protein (36kD). Con rmed by Western blotting using rat retina and olfactory bulb. A band corresponding to Cx36 homodimers may be observed at ~66kD. Species Crossreactivity: rat and human.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.