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Abs to Connexin, Junction Proteins
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Anti -Connexin 40 (CX40, Gap Junction alpha 5 Protein, CXA-5)
Anti -Connexin 40 (CX40, Gap Junction alpha 5 Protein, CXA-5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Serum |
B IF |
|
| Catalog # | C7856-02H | | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. SUBUNIT | A connexon is composed of a hexamer of connexins. | | Cellular Localization | Membrane; multi-pass membrane protein. | | Tissue Specificity | Highly expressed in lung. Belongs to the connexin family. Alpha-type (group II) subfamily. | | Applications | Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Sheep | | Source | Rat | | Concentration | ~1mg/ml | | Form | Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material. | | Purity | Serum | | Immunogen | A synthetic peptide (SLVQGLTP PPDFNQCLK) as part of rat Connexin-40 protein (aa: 253-269) conjugated to diphtheria toxoid. | | Specificity | Western blotting of cell membarnes of COS cells transiently transfected with cDNA encoding Connexin-40 shows two bands of molecular weight 38 and 40kD which are abolished by preincubation with the immunising peptide. No such bands are detected in western blots of membranes from non-transfected cells or cells transfected with cDNA encoding Connexin-37, Connexin-43 or Connexin-45. Species Crossreactivity: This antiserum recognizes Connexin-40 in rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | CX40, Gap Junction alpha 5 Protein, CXA-5, Gja5, Cxn-40 |
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