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Abs to Connexin, Junction Proteins
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Anti -Connexin 43, phosphorylated (Ser368) (Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1)
Anti -Connexin 43, phosphorylated (Ser368) (Gap junction alpha-1 protein, Cx43,
Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 (Cx43) forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Cx43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Cx43 that results in a decrease in gap junction permeability. (1-4) | | | Catalog # | C7857-01C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Rat | | Concentration | As reported | | Form | 10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin43. | | Specificity | Recognzies Connexin 43, phosphorylated at Ser368. Species Crossreactivity: Human, mouse, primate, and rat based on 100% antigen sequence homology. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1 |
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