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Abs to Connexin, Junction Proteins
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Anti -Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart Protein, GJA1, GJAL)
Anti -Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart
Protein, GJA1, GJAL)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 (Cx43) forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Cx43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Cx43 that results in a decrease in gap junction permeability. | | | Catalog # | C7857-01G | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot:1:500-1:1,000 | | Immunohistochemistry:1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human Connexin43 around the phosphorylation site of serine 367 (R-A-SP-S-R). | | Specificity | Recognizes human connexin. Species Cross-Reactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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