Anti -Connexin 43 (Connexin-43, Cx43, DFNB38, Gap Junction Protein alpha 1 43kD, Gap
Junction alpha-1 Protein, GJA1, Gap Junction 43 kD Heart Protein, GJAL, HSS, ODDD)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Connexin 43 is a member of the connexin gene family and a structural component of gap junctions. Gap junction plaques consist of clusters of intercellular aqueous channels that permit bidirectional passage of ions, metabolites, and molecules of size up to 1kD between two neighboring cells and have been implicated to be important in the control of cell proliferation, differentiation, and regeneration. Connexin 43 is the main constituent of the gap junction in working cardiomyocytes, and has been the subject of numerous investigations in the context of adult cardiac function and maintenance of proper rhythm. It is believed to function as a tumor suppressor gene. It has been mapped to chromosome 6q21-q23.2. The protein is usually expressed in the heart and fetal cochlea. Pathological role of connexin 43 has been implicated in autosomal dominant oculodentodigital dysplasia, syndactyly type III and left heart syndrome. | | | Catalog # | C7857-01K | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | HeLa, K562, and 293 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human Connexin43 around the phosphorylation site of serine 367 (R-A-SP-S-R). | | Specificity | Recognizes human Connexin 43. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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