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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 43 (Connexin-43, Cx43, DFNB38, Gap Junction Protein alpha 1 43kD, Gap Junction alpha-1 Protein, GJA1, Gap Junction 43 kD Heart Protein, GJAL, HSS, ODDD)

Anti -Connexin 43 (Connexin-43, Cx43, DFNB38, Gap Junction Protein alpha 1 43kD, Gap
Junction alpha-1 Protein, GJA1, Gap Junction 43 kD Heart Protein, GJAL, HSS, ODDD)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The connexins are a family of integral membrane proteins that oligomerize to form intercellular channels that are clustered at gap junctions. These channels are specialized sites of cell-cell contact that allow the passage of ions, intracellular metabolites and messenger molecules (with molecular weight less than 1-2 kD) from the cytoplasm of one cell to its opposing neighbors. They are found in almost all vertebrate cell types, and somewhat similar proteins have been cloned from plant species. Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43, the major protein of gap junctions in the heart, and gap junctions is thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.
Catalog #C7857-01L
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 10-20ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlTestis, seminiferous tubules and leydig cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal domain of human Connexin 43.
SpecificityRecognizes human Connexin 43.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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