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Abs to Connexin, Junction Proteins
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Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1, GJA1, GJAL, Gap junction 43kD heart protein)
Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1, GJA1, GJAL, Gap junction
43kD heart protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Each connexin is composed of a hexamer of connexin proteins. Connexins are a multi-gene family of highly related proteins. At least a dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner. Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals. Connexin-43, also known as Gap Junction Alpha-1 (GJA1), belongs to the class II (alpha) group of connexins and is expressed in the heart and fetal cochlea. | | | Catalog # | C7857-01M | | Applications | Suitable for use in Immunohistochemistry, Western blot. Other applications have not been tested. | | Recommended Dilutions | Western Blot: 0.5-1ug/ml | | Immunohistochemistry (formalin fixed and paraffin): 1-2ug/ml. Antigen retrieval is required. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Dilute in PBS (pH 7.4). Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml after reconstitution | | Form | Supplied as a lyophilized powder in PBS pH 7.4, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitute in 100ul of sterile ddH2O. | | Purity | Purified by Immunoaffinity chromatography. | | Immunogen | A synthetic peptide corresponding to the amino acids 366-382 from the C-terminus of human Connexin-43. | | Specificity | Recognizes Connexin-43. Species crossreactivity: human, mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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