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You are here:Home » Antibodies » Antibodies-Connexin, Junction Proteins » Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1, GJA1, GJAL, Gap junction 43kD heart protein)

Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1, GJA1, GJAL, Gap junction
43kD heart protein)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Each connexin is composed of a hexamer of connexin proteins. Connexins are a multi-gene family of highly related proteins. At least a dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner. Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals. Connexin-43, also known as Gap Junction Alpha-1 (GJA1), belongs to the class II (alpha) group of connexins and is expressed in the heart and fetal cochlea.
Catalog #C7857-01M
ApplicationsSuitable for use in Immunohistochemistry, Western blot. Other applications have not been tested.
Recommended DilutionsWestern Blot: 0.5-1ug/ml
Immunohistochemistry (formalin fixed and paraffin): 1-2ug/ml. Antigen retrieval is required.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Dilute in PBS (pH 7.4). Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
Concentration~1mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS pH 7.4, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitute in 100ul of sterile ddH2O.
PurityPurified by Immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to the amino acids 366-382 from the C-terminus of human Connexin-43.
SpecificityRecognizes Connexin-43. Species crossreactivity: human, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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