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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -GJA1 (Gap Junction alpha-1 Protein, Connexin-43, Cx43, Gap Junction 43kD Heart Protein, GJAL)

Anti -GJA1 (Gap Junction alpha-1 Protein, Connexin-43, Cx43, Gap Junction 43kD Heart
Protein, GJAL)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.
Catalog #C7857-01N
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2-4ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 1:25
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a segment of the 3rd cytoplasmic domain of rat connexin 43.
SpecificityRecognizes rat GJA1. Species sequence homology: human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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