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You are here:Home » Antibodies » Antibodies-Connexin, Junction Proteins » Anti -Connexin 43, NT (Gap Junction alpha-1 Protein, Connexin 43, Cx43, Gap Junction 43kD Heart Protein, GJA1, GJAL)

Anti -Connexin 43, NT (Gap Junction alpha-1 Protein, Connexin 43, Cx43, Gap Junction 43kD
Heart Protein, GJA1, GJAL)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.
Catalog #C7857-02C
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 107-138 in the N-terminal region of human Connexin-43, UniProt Accession #P17302. Species sequence homology: Bovine, Xenopus.
SpecificityRecognizes human Connexin 43. Species Crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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