Anti -Connexin 43, phosphorylated (Ser368) (Connexin-43, Connexin43, Cx43, Cx43alpha1,
AU042049, AW546267, DFNB38, Gap Junction alpha-1 Protein, Gap Junction 43kD Heart Protein,
Gap Junction alpha-1 Protein, Gap Junction Protein alpha 1 43kDa, GJA1, Gap Junctio
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). | | | Catalog # | C7857-03P | | A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes (3). | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | As reported | | Form | Supplied as a liquid in 10mM HEPES, pH7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to an aa sequence within connexin43 which includes phosphorylated Ser368. | | Specificity | Recognizes rat at 43kD Connexin43, when phosphorylated at Ser368. Species sequence homology: zebrafish, chicken, guinea pig, mouse, canine, human and bovine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Gap Junction Protein alpha 1 43kD, HGNC:4282, HGNC:8112, Npm1 |
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Download Specifications for Anti -Connexin 43, phosphorylated (Ser368) (Connexin-43, Connexin43, Cx43, Cx43alpha1, AU042049, AW546267, DFNB38, Gap Junction alpha-1 Protein, Gap Junction 43kD Heart Protein, Gap Junction alpha-1 Protein, Gap Junction Protein alpha 1 43kDa, GJA1, Gap Junctio |
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