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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 43, phosphorylated (Ser368) (Connexin-43, Cx43, Cxn-43, Gap Junction 43 kD Heart Protein, Gap Junction alpha-1 Protein, Gap Junction Protein alpha 1, Gja1, MGC93610)

Anti -Connexin 43, phosphorylated (Ser368) (Connexin-43, Cx43, Cxn-43, Gap Junction 43 kD
Heart Protein, Gap Junction alpha-1 Protein, Gap Junction Protein alpha 1, Gja1, MGC93610)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of Connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
Catalog #C7857-03Q
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlRat hippocampal lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to amino acid residues surrounding the phosphorylated (Ser368) of rat connexin43.
SpecificityRecognizes rat Connexin43, phosphorylated at (Ser368). Species Sequence Homology: human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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